Patent No. EP3626737 (titled "A Method Of Increasing The Productivity Of Eucaryotic Cells In The Production Of Recombinant Fviii") was filed by Octapharma on May 14, 2012. The application was issued on Nov 29, 2023.
Increasing yield of recombinant human factor VIII (rFVIII) during cell cultivation by applying controlled mechanical stress to the cells through increased power input, such as higher stirring rates, to induce shear forces that enhance protein production.

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