Patent No. EP3645553 (titled "Tropism-Modified Recombinant Viral Particles And Uses Thereof For The Targeted Introduction Of Genetic Material Into Human Cells") was filed by Regeneron Pharmaceuticals on Jun 27, 2018. The application was issued on Mar 15, 2023.
Recombinant viral capsid that optimizes the problems inherent in previous retargeting strategies by utilizing a first member and a second cognate member of a specific binding pair, which first member and second cognate member specifically interact to form an isopeptide bond. The first member, when displayed on a capsid protein, acts as a scaffold for any targeting ligand fused to the second cognate member, but upon binding of the first member and second cognate member, an isopeptide bond forms, and the recombinant viral particle acts as a one-component targeting vector.

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