Patent No. EP3689383 (titled "Chimeric Antigen Receptors Targeting B-Cell Maturation Antigen") was filed by The United States OF America on Mar 15, 2013. The application was issued on Dec 31, 2025.
A pharmaceutical composition comprising T-cells engineered to express a chimeric antigen receptor (CAR) that targets B-cell Maturation Antigen (BCMA) for the treatment of multiple myeloma. The CAR comprises an antigen recognition moiety directed against BCMA and a T-cell activation moiety that includes a transmembrane domain and an intracellular signaling domain. The composition is administered to patients with multiple myeloma to induce antigen-specific T-cell responses against BCMA-expressing cancer cells.
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